After conducting a feasibility study at The Polytechnic University of Milan, Adriana Santanocito and Enrica Arena patented the technology and co-founded Orange Fiber in 2014. They presented the first prototypes of fabric from their process that same year. Since its founding, the company has received funding and awards from several European brands, NGOs, and government programs. In 2017, Salvatore Ferragamo presented the first fashion collection made with Orange Fiber fabric. Orange Fiber then partnered with H&M for their Conscious Exclusive collection in 2019.